Jul 22, 2008 11:00PM

Huddersfield academic pens pioneering wound care book - 'lower extremity wounds: a problem-based approach'

A senior lecturer at the University of Huddersfield recently celebrated the publication of her first book. Dr Karen Ousey, of the Department of Adult and Children's Nursing in the School of Human and Health Sciences, co-edited the textbook with former Huddersfield academic Dr. (Source: Dermatology News From Medical News Today)

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Jul 22, 2008 11:00PM

Safe and effective solution to wrinkles found in carbon dioxide laser resurfacing

A study published in the July/August issue of Archives of Facial Plastic Surgery finds that carbon dioxide laser resurfacing is an effective long-term treatment for facial wrinkles. In carbon dioxide laser resurfacing, a laser blasts water molecules inside and outside of cells, which vaporizes the water and causes heat damage to the surrounding tissue. (Source: Dermatology News From Medical News Today)

Jul 22, 2008 12:53PM

How to measure uva protection afforded by sunscreen products

The availability of new and highly potent UVA filters represents a major advance in the development of sunscreen products. The need exists to develop a robust method to evaluate the effectiveness of UVA sunscreens, in addition to the more common UVB. Expert Review of Dermatology (Source: Medscape Dermatology Headlines)

Jul 22, 2008 11:30AM

Metastatic basal cell carcinoma presenting with unilateral upper extremity edema and lymphatic spread.

Metastatic basal cell carcinoma presenting with unilateral upper extremity edema and lymphatic spread.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S1-3

Authors: Soleymani AD, Scheinfeld N, Vasil K, Bechtel MA

Basal cell carcinoma (BCC), the most common human malignancy, metastasizes in 0.0028% to 0.5% of cases, usually to the lymph nodes, lungs, bones, and skin. After metastatic spread of BCC, survival averages 1 to 2 years. Chemotherapy, radiotherapy, and surgery are treatment options. We describe metastatic basal cell carcinoma to the skin presenting with unilateral upper extremity edema.

PMID: 18625368 [PubMed - in process]

Jul 22, 2008 11:30AM

Neutrophilic dermatoses with acute myeloid leukemia associated with an increase of serum colony-stimulating factor.

Neutrophilic dermatoses with acute myeloid leukemia associated with an increase of serum colony-stimulating factor.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S10-2

Authors: Uhara H, Saida T, Nakazawa H, Ito T

We report a case of acute myeloid leukemia with folliculitis, Sweet's syndrome, and neutrophilic panniculitis after remission induction chemotherapy for acute myeloid leukemia. The level of endogenous granulocyte colony-stimulating factor was closely associated with disease activity.

PMID: 18625369 [PubMed - in process]

Jul 22, 2008 11:30AM

Disseminated trichosporon inkin and histoplasma capsulatum in a patient with newly diagnosed aids.

Disseminated Trichosporon inkin and Histoplasma capsulatum in a patient with newly diagnosed AIDS.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S13-5

Authors: David C, Martin DB, Deng A, Cooper JZ

Histoplasma capsulatum and Trichosporon inkin may cause disseminated disease in immunocompromised patients. Disseminated T inkin, the causative agent of white piedra, is rare and difficult to diagnose. We report the case of a 28 year-old man with newly diagnosed HIV infection who developed asymptomatic lesions on his trunk and extremities. Histology demonstrated perivascular and intravascular budding yeasts. Blood cultures revealed fungal organisms that were difficult to culture. Specimens were positive for H capsulatum (confirmed by DNA probe) and T inkin. Compared with disseminated histoplasmosis, disseminated Trichosporon is relatively uncommon. Physicians should be aware of this agent in immunocompromised hosts.

PMID: 18625370 [PubMed - in process]

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Jul 22, 2008 11:30AM

Central nervous system involvement in patients with mycosis fungoides and cutaneous large-cell transformation.

Central nervous system involvement in patients with mycosis fungoides and cutaneous large-cell transformation.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S16-22

Authors: Vu BA, Duvic M

Central nervous system (CNS) involvement in mycosis fungoides (MF) is a rare occurrence with devastating consequences. Large-cell transformation (LCT) of MF is associated with a poor prognosis and increased extracutaneous manifestations. In this report, we present 5 patients with MF, LCT, and CNS disease to better define their presentation, treatment, and prognosis and present critical differences they have compared with their nontransformed counterparts. We found that patients with LCT and MF are at increased risk of CNS involvement. In addition, whereas patients with nontransformed MF typically have significant skin and visceral involvement at the time of CNS disease, some patients with LCT have no extracutaneous symptoms and their skin MF is in remission at the time of CNS presentation. Transformed patients tend to present with speech and visual difficulties secondary to mass lesions. Therefore, we recommend at least annual screening of patients with transformed MF for CNS disease with head computerized tomography with orbital cuts.

PMID: 18625371 [PubMed - in process]

Jul 22, 2008 11:30AM

Ectomesenchymal chondromyxoid tumor of the anterior aspect of the tongue.

Ectomesenchymal chondromyxoid tumor of the anterior aspect of the tongue.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S23-4

Authors: Seckin D, Demirkesen C, Gurbuz O

Ectomesenchymal chondromyxoid tumor of the anterior aspect of the tongue is a benign rare tumor. Thirty cases have been reported so far. It presents as a slowly growing, asymptomatic, submucosal nodule on the anterior dorsum of the tongue. Histopathologically, the tumor is composed of a well-circumscribed, lobular proliferation of fusiform and ovoid cells in a chondromyxoid background. Most consistent immunohistochemical finding is the diffuse and strong immunoreactivity for glial fibrillary acid protein. Histogenetic origin of the tumor is uncertain. We report here a 56-year-old woman with a 0.7-cm tumoral lesion of 5 months' duration on the anterior aspect of her tongue. Total excision was performed and histopathologic findings were consistent with ectomesenchymal chondromyxoid tumor. No recurrence was observed after 2 years of follow-up.

PMID: 18625372 [PubMed - in process]

Jul 22, 2008 11:30AM

Interstitial granulomatous drug reaction to anakinra.

Interstitial granulomatous drug reaction to anakinra.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S25-7

Authors: Regula CG, Hennessy J, Clarke LE, Adams DR, Ioffreda MD, Graber EM, Helm KF

Interstitial granulomatous drug reactions are an uncommon entity presenting as asymptomatic, annular, erythematous to violaceous plaques. The incidence of such reactions has been increasing with the use of biologic agents. We report, to the best of our knowledge, the first such reaction to the interleukin (IL)-1 inhibitor anakinra. Our patient presented with pink dermal plaques and nodules in the periaxillary region which resolved with discontinuation of anakinra and recurred upon restarting anakinra. Biopsy revealed a diffuse dermal infiltrate of lymphocytes and histiocytes with interspersed neutrophils and eosinophils. Fragmentation and degeneration of collagen and elastic fibers was also present. Withdrawal of anakinra led to complete resolution of the lesions. Interstitial granulomatous drug reactions are increasing in frequency and we add anakinra to the list of causative agents.

PMID: 18625373 [PubMed - in process]

Jul 22, 2008 11:30AM

Aberrant aquaporin 5 expression in the sweat gland in aquagenic wrinkling of the palms.

Aberrant aquaporin 5 expression in the sweat gland in aquagenic wrinkling of the palms.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S28-32

Authors: Kabashima K, Shimauchi T, Kobayashi M, Fukamachi S, Kawakami C, Ogata M, Kabashima R, Mori T, Ota T, Fukushima S, Hara-Chikuma M, Tokura Y

Aquagenic wrinkling of the palms (AWP) is an uncommon disease characterized by the rapid and transient formation of edematous whitish plaques on the palms on exposure to water. Although this disease is occasionally accompanied by hyperhidrosis, the pathophysiology of AWP remains unknown. Herein we describe a patient with AWP. The location of wrinkling was limited to the areas positive for iodine-starch test after water exposure, which suggests that AWP is etiologically related to hyperhidrosis. Histologic examination revealed hyperplastic and papillated eccrine glandular epithelium with the enlarged diameter of eccrine coils. Immunohistochemically, while aquaporin 5 (AQP5), one of the water channel AQP families, was present exclusively in the dark cells of sweat glands of healthy donors, an aberrant AQP5 staining, extending to the clear cells, was found in the patient with AWP. The hyperplastic glandular epithelium and aberrant AQP5 staining in the patient's sweat glands suggest that AWP stems from dysregulation of sweating.

PMID: 18625374 [PubMed - in process]

Jul 22, 2008 11:30AM

Melanosis of the areola and nipple.

Melanosis of the areola and nipple.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S33-4

Authors: Sceppa JA, Smith BL, Marghoob AA, Gottlieb GJ

PMID: 18625375 [PubMed - in process]

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Jul 22, 2008 11:30AM

Single hippocratic (clubbed) finger revealing an underlying enchondroma.

Single hippocratic (clubbed) finger revealing an underlying enchondroma.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S34-5

Authors: Coto-Segura P, Mallo-Garcia S, Braña A, Santos-Juanes J

PMID: 18625376 [PubMed - in process]

Jul 22, 2008 11:30AM

Fibroepithelial polyp of glans penis in a man who practiced genital hanging kung fu.

Fibroepithelial polyp of glans penis in a man who practiced genital hanging kung fu.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S35-7

Authors: Tsai TF, Hung CS, Hsiao CH

PMID: 18625377 [PubMed - in process]

Jul 22, 2008 11:30AM

Chronic cutaneous disseminated trichosporon asahii infection in a nonimmunocompromised patient.

Chronic cutaneous disseminated Trichosporon asahii infection in a nonimmunocompromised patient.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S37-9

Authors: Kim SH, Kim DH, Joo SI, Yoo JI, Kim HB, Kim NJ, Lee YS, Oh MD, Kim EC, Eun HC, Choe KW

PMID: 18625378 [PubMed - in process]

Jul 22, 2008 11:30AM

Treatment of nephrogenic systemic fibrosis with re-puva.

Treatment of nephrogenic systemic fibrosis with Re-PUVA.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S39-40

Authors: Duffy KL, Green L, Harris R, Powell D

PMID: 18625379 [PubMed - in process]

Jul 22, 2008 11:29AM

Occurrence of subacute cutaneous lupus erythematosus after treatment with fluorouracil and capecitabine.

Occurrence of subacute cutaneous lupus erythematosus after treatment with fluorouracil and capecitabine.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S4-6

Authors: Weger W, Kränke B, Gerger A, Salmhofer W, Aberer E

Capecitabine, an oral fluoropyrimidine and 5-fluorouracil (FU) prodrug recently approved for the treatment of metastatic colon and breast cancer, is currently under investigation in patients with gastric cancer. It has the advantage of oral administration, and good tolerability with its activity being comparable with intravenous 5-FU. Lupus erythematosus and lupuslike drug eruptions have been observed after 5-FU treatment, but so far no cases of subacute cutaneous lupus erythematosus have been described in patients treated either with capecitabine or 5-FU. We report a patient who developed subacute cutaneous lupus erythematosus after administration of 5-FU and capecitabine.

PMID: 18625380 [PubMed - in process]

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Jul 22, 2008 11:29AM

Common variable immunodeficiency presenting as chronic urticaria.

Common variable immunodeficiency presenting as chronic urticaria.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S40-1

Authors: Smith AA, Humphrey J, McAuley JB, Tharp MD

PMID: 18625381 [PubMed - in process]

Jul 22, 2008 11:29AM

A dermoscopic pitfall: ancient melanocytic nevus.

A dermoscopic pitfall: ancient melanocytic nevus.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S42-3

Authors: Massone C, Soyer HP, Hofmann-Wellenhof R

PMID: 18625382 [PubMed - in process]

Jul 22, 2008 11:29AM

Generalized porokeratotic eccrine ostial and dermal duct nevus associated with deafness.

Generalized porokeratotic eccrine ostial and dermal duct nevus associated with deafness.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S43-5

Authors: Jamora MJ, Celis MA

PMID: 18625383 [PubMed - in process]

Jul 22, 2008 11:29AM

Worn-down nail syndrome in a child.

Worn-down nail syndrome in a child.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S45-6

Authors: Patrizi A, Tabanelli M, Neri I, Pazzaglia M, Piraccini BM

PMID: 18625384 [PubMed - in process]

Jul 22, 2008 11:29AM

Multiple penile syringomas.

Multiple penile syringomas.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S46-7

Authors: Olson JM, Robles DT, Argenyi ZB, Kirby P, Olerud JE

PMID: 18625385 [PubMed - in process]

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Jul 22, 2008 11:29AM

Interferon-beta injection site reaction: review of the histology and report of a lupus-like pattern.

Interferon-beta injection site reaction: review of the histology and report of a lupus-like pattern.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S48-9

Authors: Conroy M, Sewell L, Miller OF, Ferringer T

PMID: 18625386 [PubMed - in process]

Jul 22, 2008 11:29AM

Congenital darier disease.

Congenital Darier disease.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S50-1

Authors: Fong G, Capaldi L, Sweeney SM, Wiss K, Mahalingam M

PMID: 18625387 [PubMed - in process]

Jul 22, 2008 11:29AM

Bilateral nevus of ito and nevus spilus in the same patient.

Bilateral nevus of Ito and nevus spilus in the same patient.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S51-2

Authors: Trindade F, Santonja C, Requena L

PMID: 18625388 [PubMed - in process]

Jul 22, 2008 11:29AM

Synovitis-acne-pustulosis-hyperostosis-osteitis syndrome: a dermatologist's diagnostic dilemma.

Synovitis-acne-pustulosis-hyperostosis-osteitis syndrome: a dermatologist's diagnostic dilemma.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S53-4

Authors: Poindexter G, Martinez S, Roubey RA, Goldsmith LA

PMID: 18625389 [PubMed - in process]

Jul 22, 2008 11:29AM

Spread of cantharidin after petrolatum use resulting in a varicelliform vesicular dermatitis.

Spread of cantharidin after petrolatum use resulting in a varicelliform vesicular dermatitis.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S54-5

Authors: Shah A, Treat J, Yan AC

PMID: 18625390 [PubMed - in process]

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Jul 22, 2008 11:29AM

Symmetrical giant facial plaque-type juvenile xanthogranuloma.

Symmetrical giant facial plaque-type juvenile xanthogranuloma.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S56-7

Authors: Gunson TH, Birchall NM

PMID: 18625391 [PubMed - in process]

Jul 22, 2008 11:29AM

Repigmentation of vitiligo during efalizumab.

Repigmentation of vitiligo during efalizumab.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S57-8

Authors: Wakkee M, Assen YJ, Thio HB, Neumann HA

PMID: 18625392 [PubMed - in process]

Jul 22, 2008 11:29AM

Dapsone-responsive histiocytoid sweet's syndrome associated with crohn's disease.

Dapsone-responsive histiocytoid Sweet's syndrome associated with Crohn's disease.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S58-60

Authors: Spencer B, Nanavati A, Greene J, Butler DF

PMID: 18625393 [PubMed - in process]

Jul 22, 2008 11:29AM

Intertriginous and follicular eruption to anticytotoxic t-lymphocyte antigen 4 monoclonal antibody.

Intertriginous and follicular eruption to anticytotoxic T-lymphocyte antigen 4 monoclonal antibody.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S60-1

Authors: Lim JL, Dahiya M, Burgin S

PMID: 18625394 [PubMed - in process]

Jul 22, 2008 11:28AM

Cutaneous myxoid fibroblastoma.

Cutaneous myxoid fibroblastoma.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S61-4

Authors: Lo LK, Hsiao CH, Chen YF, Hung CM, Tsai TF

PMID: 18625395 [PubMed - in process]

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Jul 22, 2008 11:28AM

Treatment of extra-abdominal aggressive fibromatosis with pegylated interferon.

Treatment of extra-abdominal aggressive fibromatosis with pegylated interferon.

J Am Acad Dermatol. 2008 Aug;59(2 Suppl 1):S7-9

Authors: Stengel G, Metze D, Dörflinger B, Luger TA, Böhm M

Aggressive fibromatosis (desmoid tumor) is a very rare neoplasm arising from the musculoaponeurotic structures. It is characterized by locally aggressive growth, and a tendency to relapse but not to metastasize. We report on a young woman with a large desmoid tumor of the left foot. Multiple operations and radiotherapy had resulted in local recurrences. Long-term immunointervention with pegylated interferon alfa-2b, however, led to marked clinical improvement of the patient's condition and a radiologically proven stabilization of the disease.

PMID: 18625396 [PubMed - in process]

Jul 22, 2008 11:28AM

Kaposi sarcoma: a continuing conundrum.

Kaposi sarcoma: A continuing conundrum.

J Am Acad Dermatol. 2008 Aug;59(2):179-206

Authors: Schwartz RA, Micali G, Nasca MR, Scuderi L

Kaposi sarcoma (KS) remains a challenge. Its classic or Mediterranean form tends to be benign. In transplant recipients it may be less so. As part of the AIDS pandemic, of which it was an original defining component, it may be life-threatening. It is due to human herpesvirus-8, which is necessary but not sufficient to produce the disease. KS has a low prevalence in the general population of the United States and United Kingdom, with an intermediate rate in Italy and Greece, and a high one in parts of Africa. In Italy, hot spots include its southern regions, the Po River Valley, and Sardinia, possibly related to a high density of blood-sucking insects. An important challenge is to treat KS patients without immunocompromising them. The potential of effective anti-herpes virus therapy and the use of sirolimus in transplantation recipients have added new opportunities for KS prevention. LEARNING OBJECTIVES: At the conclusion of this learning activity, participants should be able to provide the most recent information about Kaposi sarcoma in the context in which it occurs. Its classic or Mediterranean form, its pattern in transplant recipients and others iatrogenically immunosuppressed, and its occurrence as a potentially life-threatening part of the AIDS pandemic will be stressed. Its etiology and transmission will be discussed in detail to facilitate understanding of Kaposi sarcoma and of human herpesvirus-8 infection in the general population of the United States and United Kingdom, in Italy and Greece, and in certain parts of Africa. Its therapy, including the concept of doing it without immunocompromising the patient, will be stressed. New opportunities for Kaposi sarcoma prevention will also be discussed.

PMID: 18638627 [PubMed - in process]

Jul 22, 2008 11:28AM

Prospective evaluation of surgical site infection rate among patients with mohs micrographic surgery without the use of prophylactic antibiotics.

Prospective evaluation of surgical site infection rate among patients with Mohs micrographic surgery without the use of prophylactic antibiotics.

J Am Acad Dermatol. 2008 Aug;59(2):275-8

Authors: Maragh SL, Brown MD

BACKGROUND: Antibiotics may be indiscriminately given to patients undergoing Mohs micrographic surgery (MMS) for the prevention of surgical site infections, despite a low risk of infection in these patients. OBJECTIVE: We sought to evaluate the rate of wound infections among patients undergoing MMS without the use of prophylactic antibiotics. METHODS: We prospectively evaluated 1000 consecutive patients undergoing MMS for nonmelanoma skin cancer or modified MMS/"slow Mohs" for lentigo maligna melanoma in situ. RESULTS: The overall wound infection rate among 1000 patients with 1115 tumors was 0.7% (8/1115 tumors). Five (62.5%) of 8 infections occurred on the nose with an overall 1.7% (5/302) nose infection rate. Seven (87.5%) of 8 infections occurred after flap reconstruction with an overall 2.4% (7/296) flap closure infection rate. Four (50%) of 8 infections occurred in patients requiring more than one Mohs stage for tumor clearance with a 0.8% (4/487) overall infection rate in cases requiring multiple Mohs stages. Two (25%) of 8 infections had cultures positive for oxacillin-resistant Staphylococcus aureus. No wound infections occurred in cases involving the lips or ears, skin-graft closures, or below-knee or modified MMS procedures. LIMITATIONS: This was a prospective single institution uncontrolled study. CONCLUSION: Rates of infections among patients undergoing MMS or modified MMS are exceedingly low. Indiscriminate use of antibiotics increases patient risk to adverse drug reactions and antibiotic resistance. Administration of antibiotics to patients undergoing MMS should be on a case-by-case basis according to the known risk factors combined with clinical judgment.

PMID: 18638628 [PubMed - in process]

Jul 22, 2008 11:28AM

Epidermodysplasia verruciformis-associated and genital-mucosal high-risk human papillomavirus dna are prevalent in nevus sebaceus of jadassohn.

Epidermodysplasia verruciformis-associated and genital-mucosal high-risk human papillomavirus DNA are prevalent in nevus sebaceus of Jadassohn.

J Am Acad Dermatol. 2008 Aug;59(2):279-94

Authors: Carlson JA, Cribier B, Nuovo G, Rohwedder A

BACKGROUND: The hamartoma nevus sebaceus (NS) presents at birth or early childhood as a yellowish plaque characterized histologically by variable acanthosis, papillomatosis, sebaceus hyperplasia, and proliferations of adnexal structures. Clinically apparent human papillomavirus (HPV) infection is also recognized by acanthosis and papillomatosis. OBJECTIVE: We sought to determine the prevalence and physical state of HPV DNA in NS. METHODS: DNA was retrieved from 44 formalin-fixed, paraffin-embedded samples of NS (22 with secondary tumors [eg, trichoblastoma, verruca, syringocystadenoma papilliferum] and two epidermal nevi [EN]). Nested polymerase chain reaction with multiple degenerate consensus and type-specific primers and direct sequencing of polymerase chain reaction products was performed. For selected cases, in situ hybridization using probes specific for HPV 5 and 8 and for high-risk genital-mucosal HPV types was performed. RESULTS: HPV DNA was detected in 82% of NS and both EN, and consisted of genital-mucosal HPV types in 52% (HPV 6, 16, and 33) and a diverse variety of epidermodysplasia verruciformis-associated HPV types in 61%, including well-known epidermodysplasia verruciformis HPV types (5, 8, 15, 20, 22, 24, 36, 37, 38, and 80) and putatively novel epidermodysplasia verruciformis HPV types (DL285, DL287, DL436, and alb-1, -2, -3, -5, -6, -7, -8, -10, -11, -12, and -13). HPV coinfection was frequent, found in 48% (two HPV genotypes in 35% and 3 in 13%). Of NS and EN, 42% had HPV genotypes associated with cancer (ie, HPV 5, 8, 16, 20, 33, and 38); the two most commonly identified HPV types where HPV 16 (39%) and HPV 38 (18%). No differences were detected comparing frequency of HPV DNA detected with respect to age or presence of a secondary tumor. Histologically, all NS and EN showed HPV-associated cytopathic effects (ie, perinuclear halos, altered keratohyaline granules). By in situ hybridization, 64% (18/28) were positive, showing a low-intensity, punctate nuclear signal in epidermal and adnexal keratinocytes, indicating viral integration and low viral genome copy number. LIMITATIONS: Absence of adjacent, uninvolved normal-appearing skin control samples. CONCLUSION: HPV DNA is prevalent in NS, and HPV 16, the most frequently detected genotype, appears to be integrated into the host genome. Whether HPV represents a commensal infection caused by localized cutaneous predisposition, or is an essential factor in the pathogenesis of NS is unknown. The high frequency of oncogenic HPV types implicates maternal transmission of HPV and infection of an ectodermal stem cell leading to an epigenetic mosaic and altered skin development manifested along Blaschko's lines.

PMID: 18638629 [PubMed - in process]

Jul 22, 2008 11:28AM

Hyperhidrosis and botulinum toxin: expanding horizons.

Hyperhidrosis and botulinum toxin: Expanding horizons.

J Am Acad Dermatol. 2008 Aug;59(2):332-3

Authors: Heymann WR

Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service to readers of the Journal of the American Academy of Dermatology.

PMID: 18638630 [PubMed - in process]

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Jul 22, 2008 11:28AM

Desonide foam 0.05%: safety in children as young as 3 months.

Desonide foam 0.05%: Safety in children as young as 3 months.

J Am Acad Dermatol. 2008 Aug;59(2):334-40

Authors: Hebert AA,

BACKGROUND: Desonide 0.05% was recently developed in an emulsion foam formulation. OBJECTIVE: The safety of desonide foam 0.05% in children aged 3 months to 17 years was evaluated in two phase II studies and one phase III study. METHODS: A phase II open-label study of the effect of desonide foam 0.05% on the hypothalamic-pituitary-adrenal axis was evaluated in pediatric and adolescent participants with mild-to-moderate atopic dermatitis. The phase II and III clinical efficacy studies evaluated adverse events. RESULTS: At the end of the 4-week treatment in the phase II study, 4% (3 of 75) of participants experienced mild, reversible hypothalamic-pituitary-adrenal-axis suppression. The combined safety data from the phase II and III studies revealed 6% of participants in the desonide foam group and 14% in the vehicle foam group reported adverse events (P = .0002), with application site burning as the most commonly reported adverse event (3% in the desonide foam group vs 7% in the vehicle foam group; P = .004). LIMITATIONS: The studies evaluated short-term use only. CONCLUSION: Desonide foam was safe and well tolerated in participants as young as 3 months.

PMID: 18638631 [PubMed - in process]

Jul 22, 2008 11:28AM

Film photography's limitations in imaging skin of color underlies racial imaging disparities; new digital photography features facilitate the imaging of skin of color.

Film photography's limitations in imaging skin of color underlies racial imaging disparities; new digital photography features facilitate the imaging of skin of color.

J Am Acad Dermatol. 2008 Aug;59(2):351-2

Authors: Scheinfeld N

PMID: 18638632 [PubMed - in process]

Jul 22, 2008 11:28AM

Allopurinol-induced stevens-johnson syndrome and toxic epidermal necrolysis.

Allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

J Am Acad Dermatol. 2008 Aug;59(2):352-3

Authors: Lee HY, Pang SM, Thamotharampillai T

PMID: 18638633 [PubMed - in process]

Jul 22, 2008 11:28AM

"lymphocytic vasculitis" is not urticarial vasculitis.

"Lymphocytic vasculitis" is not urticarial vasculitis.

J Am Acad Dermatol. 2008 Aug;59(2):353

Authors: Guitart J

PMID: 18638634 [PubMed - in process]

Jul 22, 2008 11:28AM

Evaluation of rashes in oncology patients.

Evaluation of rashes in oncology patients.

J Am Acad Dermatol. 2008 Aug;59(2):353-4

Authors: Ghosn S, Salman S

PMID: 18638635 [PubMed - in process]

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Jul 22, 2008 11:28AM

The role of patch testing in contact urticaria.

The role of patch testing in contact urticaria.

J Am Acad Dermatol. 2008 Aug;59(2):354-5

Authors: Nijhawan RI, Jacob SE

PMID: 18638636 [PubMed - in process]

Jul 22, 2008 11:28AM

Microfoam treatment of klippel-trénaunay syndrome and vascular malformations.

Microfoam treatment of Klippel-Trénaunay syndrome and vascular malformations.

J Am Acad Dermatol. 2008 Aug;59(2):355-6

Authors: Redondo P, Cabrera J

PMID: 18638637 [PubMed - in process]

Jul 22, 2008 11:28AM

Gadolinium is not deposited in the skin of patients with normal renal function after exposure to gadolinium-based contrast agents.

Gadolinium is not deposited in the skin of patients with normal renal function after exposure to gadolinium-based contrast agents.

J Am Acad Dermatol. 2008 Aug;59(2):356-8

Authors: Boyd AS, Sanyal S, Abraham JL

PMID: 18638638 [PubMed - in process]

Jul 22, 2008 10:48AM

Systemic therapy of paediatric atopic dermatitis: an update.

Systemic therapy of paediatric atopic dermatitis: an update.

Australas J Dermatol. 2008 Aug;49(3):123-34

Authors: Borchard KL, Orchard D

Topical therapies are the mainstay in the treatment of atopic dermatitis, and are effective in the majority of patients with mild and localized disease. In patients with widespread or recalcitrant moderate to severe dermatitis, systemic therapies may be required. The frequently used systemic therapies are immunosuppressants, immune response modifiers, anti-inflammatories, antihistamines, and antibiotics. In this article, the indications and scientific support for the use of these medications is reviewed.

PMID: 18638218 [PubMed - in process]

Jul 22, 2008 10:47AM

Select the most correct answers - multiple answers possible for questions 1-11.

Select the most correct answers - multiple answers possible for questions 1-11.

Australas J Dermatol. 2008 Aug;49(3):135-6

Authors:

PMID: 18638219 [PubMed - in process]

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Jul 22, 2008 10:47AM

Autoantibodies to basement membrane proteins bp180 and bp230 are commonly detected in normal subjects by immunoblotting.

Autoantibodies to basement membrane proteins BP180 and BP230 are commonly detected in normal subjects by immunoblotting.

Australas J Dermatol. 2008 Aug;49(3):137-41

Authors: Desai N, Allen J, Ali I, Venning V, Wojnarowska F

Autoantibodies to basement membrane proteins BP180 and BP230 are characteristic of bullous pemphigoid and other subepidermal immunobullous disorders. These antibodies are, however, reported in other pruritic dermatoses, non-bullous disorders and non-cutaneous disease. Few studies have assessed basement membrane antibodies in normal subjects; antibody prevalence in this population is not clear. This study aims to examine basement membrane zone antibodies in normal middle-aged to elderly subjects. Sera from 61 healthy subjects (majority age 50-70 years) were assessed by immunoblot, indirect immunofluorescence and enzyme-linked immunosorbent assay. Ninety-one bullous pemphigoid patients acted as positive controls. Antigenic target, antibody class and titre were examined; sera binding BP180 were assessed for reactivity to the non-collagenous 16A (NC16A) domain. Thirty-six normal subjects (59%) had antibodies to either BP180 or BP230 on immunoblot analysis. BP180 was the commonest target antigen, detected in 35 subjects; binding to the immunodominant NC16A domain was not detected. Immunofluorescence was positive in three subjects. Of the bullous pemphigoid sera, 88% were positive on immunoblot or immunofluorescence; a higher frequency had antibodies against BP230. In conclusion, significant numbers of normal healthy subjects have circulating autoantibodies to basement membrane proteins, chiefly BP180 detectable by immunoblot, but these do not bind the NC16A domain.

PMID: 18638220 [PubMed - in process]

Jul 22, 2008 10:47AM

Knowledge and perceptions about sunburn and solar keratoses in australia.

Knowledge and perceptions about sunburn and solar keratoses in Australia.

Australas J Dermatol. 2008 Aug;49(3):142-7

Authors: Raasch BA, Buettner PG

An omnibus telephone survey of 1200 adult Australians determined self-reported prevalence of and attitudes to sunburn and sunspots, knowledge of the term solar keratosis and prevalence of skin checks. Half reported they had been sunburnt in the previous year. Seventy-eight per cent considered sunburn to be extremely or very serious, while 73% considered sunspots as serious or very serious. While 29% reported currently having sunspots, 69% had never heard of the term solar keratosis, 30% had never had a skin check and 28% had their last skin check more than 12 months ago. Respondents 18-29 years old (odds ration [OR] = 2.6; P = 0.002) and men (OR = 2.4; P < 0.001) were most likely to experience multiple sunburn. Persons living in capital cities (OR = 0.63; P = 0.006) and having a university degree (OR = 0.52; P = 0.001) had reduced OR for multiple sunburns. Men (OR = 0.45; P < 0.001) were less likely to consider sunburn serious or extremely serious than women. Compared with respondents 18-29 years old, those 55 years or older were 7.4-fold more likely to have had a skin check (P < 0.001). Sun-protection campaigns need to continue using evidence-based interventions targeting younger people and men to reduce sunburn. The terms used in health promotion need to be understood by the target audience.

PMID: 18638221 [PubMed - in process]

Jul 22, 2008 10:47AM

Black heel, talon noir or calcaneal petechiae?

Black heel, talon noir or calcaneal petechiae?

Australas J Dermatol. 2008 Aug;49(3):148-51

Authors: Urbina F, León L, Sudy E

We describe a series of six patients with superficial cutaneous haemorrhages of the feet, including a classical case of black heel (talon noir) and other similar cases with diverse clinical presentations that do not match the typical description of that process. The main differences lay in production mechanism, morphology and location. The causes of these 'atypical' lesions were: burns with hot sand, friction against the rough edge of a swimming pool, wearing new shoes, jogging, or pricking a blister with a needle. Clinically, they consisted of isolated or multiple, small, large or linear, brown or black lesions located in areas that did not include the convex part of the heel, in which talon noir usually appears; on the contrary, the lesions affected the back third of the soles, the toes, periungual fold and plantar arch. As the presence of blood in the horny layer was a common final factor in all these cases, a better name for this process would be 'post-traumatic cutaneous intracorneal blood' to describe black heel and its diverse clinical presentations.

PMID: 18638222 [PubMed - in process]

Jul 22, 2008 10:47AM

From biologic to biologic to biologic: lessons to learn for erythrodermic and recalcitrant chronic plaque psoriasis.

From biologic to biologic to biologic: lessons to learn for erythrodermic and recalcitrant chronic plaque psoriasis.

Australas J Dermatol. 2008 Aug;49(3):152-5

Authors: Yip L, Harrison S, Foley P

Differences in mode of action between biologic agents could explain why one agent is more efficacious than another in the treatment of recalcitrant and erythrodermic flares of chronic plaque psoriasis. Here, we present our experience using a case series of three patients with chronic plaque psoriasis who showed consistent and similar responses to three different biologic agents. All three patients who were refractory to efalizumab developed erythrodermic flares 2-12 weeks after a direct switch to etanercept. Switching from efalizumab to etanercept could provoke paradoxical flaring of psoriasis, which might be prevented by transitioning to systemic agents. The erythrodermic flares in all three patients responded dramatically to infliximab with marked and maintained improvements in Psoriasis Area and Severity Index scores.

PMID: 18638223 [PubMed - in process]